The Amazon River flows eastward into the Atlantic Ocean from its source in the western part of South America.
Conclusion / Hypothesis
The Amazon River once flowed into the Pacific Ocean.
Evidence
The Amazon is in the western part of South America (the Pacific Ocean is to the west of South America), but it currently flows eastward into the Atlantic Ocean.
The Andes Mountains now lie in between the Amazon river and the Pacific Ocean. But there is a freshwater fish in the Amazon that descended from a salt-water fish that was found only in the Pacific.
Evaluate
These scientists are thinking that at some point the Amazon was not cut-off from the Pacific by the Andes. During that period a saltwater fish found only in the Pacific ocean evolved into a freshwater fish that lived in the Amazon and continues to, to this day.
If we were going to play devil's advocate to the hypothesis and say "no, the Amazon never flowed into the Pacific", then we would sort of need to explain how there's a fish in the Amazon that descended from a now-extinct fish that only inhabited Pacific waters.
We could also just bring up anything that would make this hypothesis implausible, for other reasons. For example, we could say,
Goal
Look for an answer that rules out a different way of explaining how a pacific saltwater fish ended up evolving into an Amazonian freshwater fish, or an answer that creates a possibility in the past for the Amazon to have flowed into the Pacific, or shows some more evidence suggesting that it did.