Reading ComprehensionDifficulty: Hard

PT117 S1 P3 Q20 Explanation

NGF

A free, expert breakdown of this official LSAT Reading Comprehension question.

TopicsInferenceScience

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Passage

The survival of nerve cells, as well as their performance of some specialized functions, is regulated by chemicals known as neurotrophic factors, which are produced in the bodies of animals, including humans. Rita Levi-Montalcini’s discovery in the 1950s of the first of these agents, a hormonelike substance now known as NGF, was led to Levi-Montalcini sharing the Nobel Prize for medicine in 1986.

In the mid-1940s, Levi-Montalcini had begun by hypothesizing that many of the immature nerve cells produced in the development of an organism are normally programmed to die. In order to confirm this theory, she conducted research that in 1949 found that, when embryos are in the process of forming their nervous systems, responsible for the effects Levi-Montalcini had observed: a protein that she named “nerve growth factor” (NGF).

NGF was the first of many cell-growth factors to be found in the bodies of animals. Through Levi-Montalcini’s work and other subsequent research, it has been determined that this substance is present in many tissues and biological fluids, and that it is especially concentrated in some organs. In developing organisms, nerve cells brain and spinal cord—die if the factor is not present or if they encounter anti-NGF antibodies.

What this question is testing

Inference

Your task

Find what must be true based on what the passage or stimulus states.

Common trap

Answers that are plausible or likely but not actually guaranteed by the text.

Winning move

Keep only the choice the statements fully support — eliminate anything that requires an extra assumption.

Reading along? Open the full official question in LawHub — we show a fragment here and keep the reasoning in our own words.

The question
20.

Which one of the following is most strongly supported by the information

Answer choices

  1. Out of Scope: other than NGF5% picked this

    Some of the effects that the author describes as occurring in Levi-Montalcini’s culture of chick embryo extract were due to

    The passage tells us that other neurotrophic factors have been discovered, other than NGF. But NGF was the factor discovered by Levi-Montalcini in her chick experiment. The final sentence of the 2nd paragraph says: Further research identified a specific substance contributed by the mouse tumors that was responsible for the effects: NGF.

  2. Unknown Comparison: more thoroughly22% picked this

    Although NGF was the first neurotrophic factor to be identified, some other such factors are

    We know that other neurotrophic factors have been discovered, but there isn't any text that makes a comparison about any of them being more thoroughly understood than is NGF. The final paragraph tells us a lot about NGF, too, so it seems like NGF is pretty well understood.

  3. Out of Scope: other factors4% picked this

    In her research in the 1940s and 1950s, Levi-Montalcini identified other neurotrophic factors in

    We only ever hear about Levi-Montalcini discovering NGF. The first sentence of the final paragraph says that NGF was the first of many cell-growth factors to be found, but it doesn't say or suggest that Levi-Montalcini found any of these other factors. The following sentence returns to talking about Levi-Montalcini because the rest of the final paragraph tells us all that we now know about NGF, some of which we learned from Levi-Montalcini's research in the 40s / 50s.

  4. Correct62% picked this

    Some neurotrophic factors other than NGF perform functions that are not specifically identified

    Why this is right

    This is as obnoxious as Inference + Undefined Target can get. They're just asking us to find a needle-in-a-haystack. And sometimes that needle is found early on, in one of the "throwaway" details we might read in the 1st paragraph. The very first sentence says that the survival of nerve cells is regulated by chemicals known as neurotrophic factors. It also says that nerve cells' performance of some specialized functions is regulated by chemicals known as neurotrophic factors. We only hear about NGF in the passage, and it regulates the survival of nerve cells. So presumably these other neurotrophic factors are involved in regulating the performance of some specialized functions of nerve cells. But those functions are not specifically identified by the passage.

    Skill tested: Inference · how this choice captures the passage's function is the move to repeat next time.

  5. Out of Scope: also caused7% picked this

    The effects of NGF that Levi-Montalcini noted in her chick embryo experiment are also caused by other neurotrophic factors

    We don't have any evidence that the other neurotrophic factors also have the effect of controlling the survival of nerve cells. The first sentence says that "survival of cells as well as performance of specialized functions is regulated by neurotrophic factors". That doesn't mean that all neurotrophic factors do both things. We can say "color of eyes as well as height are regulated by genes". That doesn't mean that every type of gene regulates eye color and height. That sentence can just mean that some genes handle eye color, other handle height.

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