Reading ComprehensionDifficulty: Hard

PT117 S1 P3 Q19 Explanation

NGF

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Passage

The survival of nerve cells, as well as their performance of some specialized functions, is regulated by chemicals known as neurotrophic factors, which are produced in the bodies of animals, including humans. Rita Levi-Montalcini’s discovery in the 1950s of the first of these agents, a hormonelike substance now known as NGF, was led to Levi-Montalcini sharing the Nobel Prize for medicine in 1986.

In the mid-1940s, Levi-Montalcini had begun by hypothesizing that many of the immature nerve cells produced in the development of an organism are normally programmed to die. In order to confirm this theory, she conducted research that in 1949 found that, when embryos are in the process of forming their nervous systems, responsible for the effects Levi-Montalcini had observed: a protein that she named “nerve growth factor” (NGF).

NGF was the first of many cell-growth factors to be found in the bodies of animals. Through Levi-Montalcini’s work and other subsequent research, it has been determined that this substance is present in many tissues and biological fluids, and that it is especially concentrated in some organs. In developing organisms, nerve cells brain and spinal cord—die if the factor is not present or if they encounter anti-NGF antibodies.

What this question is testing

Locate Detail

Your task

Pin down exactly what the question asks about the passage — a detail, the author's view, the structure, or the main point — before looking at the choices.

Common trap

Answers that restate a true detail from the passage but don't answer the specific question being asked.

Winning move

Anticipate the answer in your own words from the passage, then find the choice that matches that prediction.

Reading along? Open the full official question in LawHub — we show a fragment here and keep the reasoning in our own words.

The question
19.

The passage describes a specific experiment that tested which one of the

Answer choices

  1. Correct66% picked this

    A certain kind of mouse tumor produces a chemical that stimulates the growth

    Why this is right

    This sounds like the 2nd hypothesis we were looking for: - many of the immature nerve cells produced in the development of an organism are normally programmed to die - a chemical produced by the tumors was responsible for the observed nerve growth Was that a mouse tumor? Yes, she observed that the development of nerves in chick embryos could be stimulated by implanting a certain variety of mouse tumor in the embryos. She then hypothesized that a chemical produced by the [mouse] tumors was responsible for the observed nerve growth.

    Skill tested: Locate Detail · how this choice captures the passage's function is the move to repeat next time.

  2. Very Weak Match29% picked this

    Developing embryos initially grow many more nerve cells than they will

    This sounds like it's in the neighborhood of the first hypothesis: - many of the immature nerve cells produced in the development of an organism are normally programmed to die - a chemical produced by the tumors was responsible for the observed nerve growth But this answer doesn't capture the idea of "normally programmed to die". In fact from this answer we have no idea that these extra nerve cells do die; it's just as likely that they hang around uselessly. This isn't a good enough match for "many immature nerve cells are programmed to die".

  3. Bad Match2% picked this

    In addition to NGF, there are several other important neurotrophic factors regulating cell

    This doesn't sound remotely like either of the two hypotheses: - many of the immature nerve cells produced in the development of an organism are normally programmed to die - a chemical produced by the tumors was responsible for the observed nerve growth Neither of them talked about NGF or other neurotrophic factors.

  4. Bad Match1% picked this

    Certain organs contain NGF in concentrations much higher than in the

    This doesn't sound remotely like either of the two hypotheses: - many of the immature nerve cells produced in the development of an organism are normally programmed to die - a chemical produced by the tumors was responsible for the observed nerve growth Neither of them talked about NGF or organs or tissue.

  5. Bad Match2% picked this

    Certain nerve cells are supplied with NGF by the muscle cells to which

    This doesn't sound remotely like either of the two hypotheses: - many of the immature nerve cells produced in the development of an organism are normally programmed to die - a chemical produced by the tumors was responsible for the observed nerve growth Neither of them talked about NGF or muscle cells.

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