Zoologist: Every domesticated large mammal species now in existence was domesticated thousands of years ago.
Conclusion
Most wild large mammals today would either be difficult to domesticate or not worth domesticating.
Evidence
Every domesticated large mammal today was domesticated thousands of years ago. Since that time, people have tried tons of times to domesticate any of the wild large mammals that seemed worth domesticating.
Evaluate
It's pretty hard to disagree with this conclusion. Since people have looked at all the wild large mammals, filtered out the ones that are worth domesticating, and then tried tons of times to domesticate to domesticate each of those, it seems like whichever wild large mammals are left wild were either initially given up on because they didn't seem worth domesticating or were eventually given up on because they weren't able to domesticate them.
In order to fight this conclusion, we'd need a way to argue that most wild large mammals nowadays would be worth domesticating and not-difficult to domesticate. (Seems hard to think of an objection that would allow us to argue that)
Goal
Because the premise is about thousands of years ago but the conclusion is about "now", we're probably looking for an answer that says the author is assuming that what was true in the past is still true today.