As advances in medical research and technology have improved the ability of the medical profession to diagnose and treat a wide variety of illnesses and injuries, life spans have increased and overall health has improved.
Given that ...
Life spans have increased and overall health has improved (due to improved ability to diagnose and treat a wide variety of illnesses and injuries)
Why is it that ...
Over the past few decades there has been a steady and significant increase in the rate of serious infections?
Evaluate / Goal
We just need something that has changed that could explain why there are more serious infections nowadays.
It could relate to the change we've already heard about (improved ability to treat / diagnose diseases, or life span increasing, or health improving), or it could come from something we haven't heard about that also changed over the past few decades.
Stuff we know has changed that could explain the change - some of the new ways we treat or diagnose diseases lead to serious infections - as people's life spans get longer, that invites more serious infections - as people's health improves, that somehow (probably indirectly) leads to more serious infections
Stuff we haven't talked about that could explain the change - Over the past few decades, air pollution has worsened, which can lead to serious infections