Measurements of the motion of the planet Uranus seem to show Uranus being tugged by a force pulling it away from the Sun and the inner planets.
Conclusion (therefore)
In addition to the known planets, there must be at least one planet in our solar system that we have yet to discover.
Evidence
Measurements of Uranus show that there is a force tugging it away from the Sun and inner planets.
But Neptune and Pluto, the two known planets farther than Uranus, don't have enough mass to account for the tugging.
Evaluate
Since we're trying to solve a science mystery here, we can use our Explain Curious Fact framework.
Curious Fact ... why does it seem like Uranus is being tugged away from the Sun at a force stronger than the gravitational pull of the two farther planets (Neptune and Pluto)?
Author's Explanation ... there must be at least one planet in our solar system that we have yet to discover (and that planet exists farther from the Sun than Uranus and accounts for the rest of the outward tugging force we're measuring).
The two pressure points are always 1. Alternate Explanations for the curious fact 2. the plausibility of the author's explanation
Goal
On Weaken (and every other question type other than Strengthen), the correct answer is more likely to deal with an alternate explanation.
So let's primarily look for a different way to explain where this outward tugging force is coming from (a black hole? a planet outside our solar system? an asteroid belt? comets?).
But we'll keep an open mind for answers that would otherwise be trying to degrade the plausibility that there's another planet in the solar system we've yet to discover.