People who are allergic to cats are actually allergic to certain proteins found in the animals' skin secretions and saliva; which particular proteins are responsible, however, varies from allergy sufferer to allergy sufferer.
Given
Sentence 1 before the semi colon tell us that people with cat allergies aren't allergic to cats, per se, but to specific proteins found in their skin secretions (gross) and their saliva. After the semi colon, we're told that the specific protein responsible for the allergy varies from one person to another. Sentence 2 starts with the evidence indicator word "since" which is unusual, though not unheard of, for a Most Supported question. Typically, these are non-argument stimuli but occasionally they are arguments. When they are, the right answer tends to feel a lot like a Necessary Assumption answer, so we'll keep that in mind when we try to make a prediction. The evidence claim is that ALL cats shed skin and spread saliva (also gross), from which an equally strong conclusion is drawn: there's NO such thing as a cat that can't provoke an allergy. Sentence two ends with a concession following the concession indicator word "although" - it's common for a cat to cause a reaction for some people who suffer from cat allergies but not for others.
Evaluate
There are a lot of overlapping ideas in these two long, multi-clause sentences: cats, proteins, allergies, allergy sufferers. A correct answer could deal with any of these ideas.
Circling back to that idea of the Necessary Assumption style of prediction, we might also consider the relationship between the claim "all cats shed and spread" and the conclusion that That argument seems to assume that all cats have proteins in their skin secretions and saliva that are capable of causing an allergic reaction. Sentence 1 before the colon establishes that "certain proteins" are the source of these reactions, but it didn't go so far as to say "all proteins" of these types are capable of doing so, so that would be a Necessary Assumption style prediction.
All that being said, Most Supported questions are not the most predictable, so read the answers with an open mind. Beware of claims that are stronger than the stimulus, and get rid of answers that introduce a new idea. For this question type, new ideas are Out of Scope.