Essayist: When the first prehistoric migrations of humans from Asia to North America took place, the small bands of new arrivals encountered many species of animals that would be extinct only 2,000 years later.
Conclusion
Microorganisms on the new humans and their new animals is probably what led to a bunch of animal extinctions that occurred about 2000 years after these humans arrived in North America.
Evidence
It's implausible that hunting from these small bands of humans could have caused so many extinctions. Also, the new arrivals and their animals definitely had foreign disease-causing microorganisms on them.
Evaluation
If we want to weaken a causal hypothesis, we have to either have a different way to explain the Curious Fact or think of a way to render the author's hypothesis less plausible.
What else could have caused the extinction of many North American species, 2000 years after the arrival of humans? Maybe climatic stuff. Maybe some change in the local predator / prey dynamics. Maybe humans still caused the extinctions, but not via causing diseases or overhunting.
What would make the author's hypothesis that microorganisms from Asia led to the extinctions less plausible? Maybe the new microorganisms didn't cause any diseases virulent enough to cause extinctions. Maybe the diseases were just one of a few things, not "the crucial factor".
Goal
We need an answer that offers a different explanation for the extinctions, or an answer that undercuts the plausibility that disease-causing microorganisms were the crucial factor in the extinctions.