If one of the effects of a genetic mutation makes a substantial contribution to the survival of the species, then, and only then, will that mutation be favored in natural selection.
Statements
bi-conditional (then and only then)
if, then, effect of mutation favored in natural makes substantial selection contribution
if, then, effect of mutation not favored in doesn't make a natural selection substantial contribution
The second sentence is giving a potential exception to the first statement, saying that a mutation that leads to some good stuff (favored) and some bad stuff (not favored) can't be so negative that it cancels out the positive.
So if we were trying to amend the original rule to capture that proviso, I would just qualify the wording of the rule so that we capture this idea of .
Goal
Since this is a Must Be False question, we're anticipating that it will contradict the conditional we were provided. Contradicting a conditional usually means saying the Left side is true but the Right side is false.
But contradicting a bi-conditional works either way.
We know: if a mutation offers a net gain, it's favored. if it doesn't offer a net gain, it's not favored.
So a must be false would be either of these: - this mutation is favored / doesn't offer a net gain - this mutation is favored / does offer a net gain