The interstitial nucleus, a subregion of the brain’s hypothalamus, is typically smaller for male cats than for female cats.
Conclusion (Thus)
The size of the interstitial nucleus determines whether or not male cats can contract disease X.
Evidence
A neurologist performed autopsies on male cats who died from X and found that these male cats had interstitial nuclei that were as large as those generally found in female cats.
Evaluate
Since the author is concluding something causal (the size of Y determines whether you can contract X) based off a correlation (male cats with X were more likely to have bigger interstitial nuclei than average male cats), we are in familiar Explain the Curious Fact territory.
Curious Fact ... why did these male cats who died of X have bigger than average interstitial nuclei?
Author's Explanation ... having a big interstitial nucleus makes it possible for a male cat to contract disease X (the ones with regular sized interstitial nuclei cannot contract disease X).
Goal
Since this is Weaken, we would want to either
1. suggest an Alternate Explanation for the Curious Fact why else could it be that the cats who died from X had bigger than average interstitial nuclei? maybe (Reverse Cause) the disease itself causes your interstitial nucleus to enlarge? maybe (Third Factor) there's some genetic condition where a male cat is born with certain female traits, such as the bigger interstitial nucleus, and that genetic condition is ultimately what causes susceptibility to disease X.
or
2. undermine the plausibility of the Author's Explanation what could make it seem less likely that size of interstitial nucleus has any causal bearing on whether male cats can contract X?