Logical ReasoningDifficulty: Hard

PT106 S3 Q25 Explanation

The interstitial nucleus, a subregion

A free, expert breakdown of this official LSAT Logical Reasoning question.

TopicsWeaken

Keep going in LSAT Lab

  • Save & drill this skill build targeted practice sets from questions like this one

  • Video walkthroughs watch every question solved step by step

  • 81 official LSATs as questions, timed sections & full-length tests

Full official LSAT questions are available through LawHub. This page provides LSAT Lab's explanation, strategy, and review tools without republishing the full official question.

Stimulus

The interstitial nucleus, a subregion of the brain’s hypothalamus, is typically smaller for male cats than for female cats. A neurobiologist performed autopsies on male cats who died from disease X, a disease affecting no more than .05 percent of male cats, and found that these male cats had interstitial nuclei that interstitial nucleus determines whether or not male cats can contract disease X.

What this question is testing

Weaken

Your task

Find the choice that makes the argument's conclusion less likely to be true.

Common trap

Answers that look negative but attack a claim the argument never relied on.

Winning move

Find the assumption the argument depends on, then pick the choice that undermines it.

Reading along? Open the full official question in LawHub — we show a fragment here and keep the reasoning in our own words.

The question
25.

Which of the following statements, if true, most seriously weakens

Answer choices

  1. Unclear Impact7% picked this

    No female cats have been known to contract disease X, which is a subtype

    Females have large interstitial nuclei (the same size as the interstitial nucleus of the male cats who got disease X). Since the females don't get X even though they have big interstitial nuclei, it somewhat seems to weaken the plausibility of the author's idea that big interstitial nuclei in male cats is what enables them to get disease X. So, this feels a little like Effect without Cause, because it's giving Big Interstitial + No Disease X. But it's not really giving "big interstitial" because female cats naturally have a larger interstitial nucleus. For the male cats, a nucleus this big was abnormal and thus more likely to be associated with a disease. The text also tells us that disease X is "a disease affecting no more than 0.05% of male cats". It's not clear whether that means it only affects male cats or whether it could affect both sexes of cats.

  2. No Impact7% picked this

    Many male cats who contract disease X also contract disease Z, the cause of

    Since we know nothing about disease Z, this fact doesn't help us evaluate anything about whether disease X in male cats is causally connected to the size of their interstitial nucleus.

  3. Strengthens9% picked this

    The interstitial nuclei of female cats who contract disease X are larger than those of female cats who

    This adds plausibility to the Author's Causal Explanation, that the bigger interstitial nucleus in these male cats is what caused them to contract disease X.

  4. Unclear Impact30% picked this

    Of 1,000 autopsies on male cats who did not contract disease X, 5 revealed interstitial nuclei larger than those

    This may feel like a Cause without Effect plausibility weakener, since it's talking about male cats who had the bigger nuclei but didn't contract disease X. However, it's not clear how much we should care about this fact. The male cats who died of X had interstitial nuclei that were as large as a female cat's. The male cats in this answer choice had "larger than average" interstitial nuclei, but we don't know if they were as large as those of a female cat. Also, this would only weaken the argument if we thought the author was saying that "male cats with larger nuclei will get disease X". The author is only concluding that "male cats with larger nuclei can get disease X".

  5. Correct48% picked this

    The hypothalamus is known not to be causally linked to disease Y, and disease X is a

    Why this is right

    This badly hurts the plausibility of the Author's Explanation. It essentially denies the possibility of a causal mechanism by which the interstitial nucleus could have influence over disease X. But to make this idea harder to understand, the answer refers to higher categories. Hypothalamus is a bigger category that includes the subregion of the interstitial nucleus. Disease Y is a bigger category that includes the subtype of Disease X. If hypothalamus is known not be causally linked to disease Y, then it seems pretty unlikely that the interstitial nucleus has any causal link to disease X.

    Skill tested: Weaken · how this choice captures the argument's function is the move to repeat next time.

Continue the review in LSAT Lab

Save this question, watch the video walkthrough, and drill similar questions in your LSAT Lab account.

LSAT Lab

Turn this review into a targeted study plan.

Save this question, drill more like it, watch the video walkthrough, and track your progress in your LSAT Lab account.

Start practicing free