Wirth: All efforts to identify a gene responsible for predisposing people to manic-depression have failed.
Where's the Disagreement
Does C disagree with W's first claim? Is C saying that ? No. He says "I do not dispute your evidence".
Does C disagree with W's second claim? Is C saying that ? No, he's saying that researchers might now be thinking there's a manic-depression cluster of genes.
Does C disagree with W's final claim? Yes, C says that he disputes W's conclusion. W concluded that C is saying, And this is because there's a cluster of genes that interact in complex ways to create a vulnerability to manic-depression.
Goal
The point at issue is whether or not a genetic predisposition to manic-depression would be found in only one gene vs. could be found in the interactions between a set of genes.